Docking Protein 6 (DOK6) Antibody

Background

DOK6 is an adaptor protein in the DOK family that interacts with RET and other receptor tyrosine kinases, promoting neuronal development and survival. It is highly expressed in the nervous system, particularly in sensory and motor neurons, where it regulates neurite outgrowth and axonal guidance through the activation of MAPK/ERK pathways. DOK6 interacts with signaling proteins via its PTB and PH domains to mediate downstream effects. It plays a role in neurotrophic signaling, and its dysregulation is linked to impaired neural differentiation and neurodevelopmental disorders. Studies highlight its importance in promoting axonal elongation and neuronal connectivity.