anti- DOCK6 antibody

Name: anti- DOCK6 antibody
Brand: FineTest
SKU: FNab02496
Availability: OnlineOnly

Este producto es parte de DOCK - Dedicator of Cytokinesis

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-DOCK6

proveedor

FineTest

reference

FNab02496

Tested Applications

ELISA, WB, IHC

reactivity

human

status

RUO

clonality

polyclonal

Descripción

Acts as guanine nucleotide exchange factor(GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth(By similarity).

Background

DOCK6 is a dual GEF for Rac1 and Cdc42, critical for cytoskeleton regulation, neurite outgrowth, and axonal growth. It facilitates actin and microtubule dynamics, influencing processes like neuronal development and fibroblast migration. DOCK6 mutations are associated with Adams-Oliver syndrome, characterized by limb and scalp defects due to impaired cell migration. It is expressed in neural and connective tissues, where it regulates cellular polarity and adhesion. DOCK6 interacts with Rac1 to drive membrane protrusion and lamellipodia formation. Knockdown studies show defects in axonal elongation and cellular migration, underscoring its role in tissue development and repair.

Características del producto

clonality

polyclonal

reactivity

human

immunogen target

dedicator of cytokinesis 6

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB, IHC

observerd MW

Q96HP1

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB:1:200-1:1000; IHC: 1:50-1:500

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

DOCK6

alias

DOCK6, KIAA1395,AOS2, ZIR1

uniprot id

https://www.uniprot.org/uniprotkb/Q96HP0

gene id

https://www.ncbi.nlm.nih.gov/gene/57572

note

This product is for research use only.

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