anti- DOCK6 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
anti- DOCK6 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02496
tested applications
ELISA, WB, IHC
Description
Acts as guanine nucleotide exchange factor(GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth(By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | dedicator of cytokinesis 6 |
| Host | Rabbit |
| Reactivity | human |
| Recommended Dilution | WB:1:200-1:1000; IHC: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Q96HP1 |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q96HP0 |
| Gene ID | 57572 |
| Alias | DOCK6, KIAA1395,AOS2, ZIR1 |
| Background | Antibody anti-DOCK6 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
DOCK6 is a dual GEF for Rac1 and Cdc42, critical for cytoskeleton regulation, neurite outgrowth, and axonal growth. It facilitates actin and microtubule dynamics, influencing processes like neuronal development and fibroblast migration. DOCK6 mutations are associated with Adams-Oliver syndrome, characterized by limb and scalp defects due to impaired cell migration. It is expressed in neural and connective tissues, where it regulates cellular polarity and adhesion. DOCK6 interacts with Rac1 to drive membrane protrusion and lamellipodia formation. Knockdown studies show defects in axonal elongation and cellular migration, underscoring its role in tissue development and repair.
Related Products
anti- DOCK6 antibody
Acts as guanine nucleotide exchange factor(GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth(By similarity).
Ver Producto
Recombinant Human DOCK6
Ver Producto