Docking Protein 5 (DOK5) Antibody (Biotin)
169€ (20 µg)
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935106861
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name
Docking Protein 5 (DOK5) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx105355
tested applications
ELISA
Description
Docking protein 5 Antibody (Biotin) is a Rabbit Polyclonal antibody against Docking protein 5 conjugated to Biotin.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Docking Protein 5 (DOK5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9P104 |
| Gene ID | 55816 |
| NCBI Accession | NP_060901.2, NM_018431.4 |
| OMIM | 608334 |
| Alias | Downstream of tyrosine kinase 5,C20orf180,IRS-6,IRS6,Insulin receptor substrate 6 |
| Background | Antibody anti-DOK5 |
| Status | RUO |
Descripción
DOK5 is a member of the DOK family, functioning as an adaptor protein in signaling pathways downstream of RET and insulin receptors. It is expressed in skeletal muscle, heart, and nervous tissue, where it regulates processes like cell survival, differentiation, and metabolic signaling. DOK5 enhances insulin signaling by activating the MAPK/ERK pathway but does not influence the PI3K/Akt pathway. It is critical for neurite outgrowth and neuronal development, particularly in response to neurotrophic factors. Dysregulation of DOK5 contributes to insulin resistance and is implicated in neurological disorders, where it affects neuronal survival and axonal guidance.
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