Docking Protein 3 (DOK3) Antibody
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935106861
info@markelab.com
Precio
162.5€ (20 µg)
Antibody anti-DOK3
proveedor
Abbexareference
abx318238Tested Applications
ELISA, WB, IHC, IF/ICCreactivity
Human, Mousestatus
RUOclonality
PolyclonalDescripción
DOK3 Antibody is a Rabbit Polyclonal against DOK3.
Background
Docking protein 3 (DOK3) is a unique member of the DOK family, characterized by its selective expression in lymphoid tissues and its critical role in B-cell receptor (BCR) signaling. Unlike DOK1 and DOK2, DOK3 predominantly functions in modulating adaptive immune responses. It acts as a negative regulator of BCR signaling by interacting with various kinases and phosphatases, thereby preventing hyperactivation of B cells. This function is crucial for maintaining immune tolerance and preventing autoimmune disorders. DOK3 has also been implicated in the regulation of inflammation and the production of cytokines in macrophages. Dysregulation of DOK3 expression or function has been linked to immune deficiencies and certain lymphoid malignancies, highlighting its importance in immune regulation and cellular signaling pathways.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse
immunogen target
Docking Protein 3 (DOK3)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, IF/ICC
purity
> 95%
purification
Purified by Protein G.
buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
size 1
20 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
1 mg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
DOK3
dry ice
No
availability
Shipped within 5-10 working days.
alias
DOK3, DOKL, docking protein 3,Downstream of tyrosine kinase 3
uniprot id
NCBI accession
NM_024872.2
note
This product is for research use only.
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