Docking Protein 3 (DOK3) Antibody

Este producto es parte de DOK - Docking protein
Docking Protein 3 (DOK3) Antibody

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935106861

info@markelab.com

Precio

162.5€ (20 µg)

Antibody anti-DOK3

proveedor

Abbexa

reference

abx318238

Tested Applications

ELISA, WB, IHC, IF/ICC

reactivity

Human, Mouse

status

RUO

clonality

Polyclonal

Descripción

DOK3 Antibody is a Rabbit Polyclonal against DOK3.


Background

Docking protein 3 (DOK3) is a unique member of the DOK family, characterized by its selective expression in lymphoid tissues and its critical role in B-cell receptor (BCR) signaling. Unlike DOK1 and DOK2, DOK3 predominantly functions in modulating adaptive immune responses. It acts as a negative regulator of BCR signaling by interacting with various kinases and phosphatases, thereby preventing hyperactivation of B cells. This function is crucial for maintaining immune tolerance and preventing autoimmune disorders. DOK3 has also been implicated in the regulation of inflammation and the production of cytokines in macrophages. Dysregulation of DOK3 expression or function has been linked to immune deficiencies and certain lymphoid malignancies, highlighting its importance in immune regulation and cellular signaling pathways.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Mouse


immunogen target

Docking Protein 3 (DOK3)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB, IHC, IF/ICC


purity

> 95%


purification

Purified by Protein G.


buffer

0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.


size 1

20 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

1 mg


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

DOK3


dry ice

No


availability

Shipped within 5-10 working days.


alias

DOK3, DOKL, docking protein 3,Downstream of tyrosine kinase 3


NCBI accession

NM_024872.2


note

This product is for research use only.


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