Docking Protein 1 Phospho-Tyr362 (DOK1 pY362) Antibody
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Description
DOK1 (pY362) Antibody is a Rabbit Polyclonal against DOK1 (pY362).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Docking Protein 1 Phospho-Tyr362 (DOK1 pY362) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr362 |
| Recommended Dilution | WB: 1/500 - 1/1000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99704 |
| Gene ID | 1796 |
| Alias | Downstream of tyrosine kinase 1,P62DOK, pp62 |
| Background | Antibody anti-DOK1 |
| Status | RUO |
Descripción
Docking protein 1 (DOK1) serves as an adaptor protein involved in cellular signaling pathways, particularly those linked to tyrosine kinase receptors and cytokine receptors. DOK1 lacks intrinsic enzymatic activity but facilitates signal transduction by linking membrane-bound receptors to downstream effectors. It plays a critical role in regulating cell proliferation, differentiation, and apoptosis by acting as a negative regulator of mitogenic signaling pathways. DOK1 is highly expressed in hematopoietic cells and is instrumental in immune responses. Dysregulation of DOK1 has been implicated in oncogenesis, particularly in hematologic malignancies, where it acts as a tumor suppressor by inhibiting excessive cellular proliferation and survival signals. Its interactions with Ras-GAP and other signaling molecules underline its importance in maintaining cellular homeostasis.
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