Docking Protein 1 Phospho-Tyr362 (DOK1 pY362) Antibody
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Descripción del producto
DOK1 (pY362) Antibody is a Rabbit Polyclonal against DOK1 (pY362).
Documents del producto
Especificaciones del producto
| Alias | Downstream of tyrosine kinase 1,P62DOK, pp62 |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr362 |
| Availability | Shipped within 5-10 working days. |
| Background | Antibody anti-DOK1 |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Form | Liquid |
| Gene ID | 1796 |
| Host | Rabbit |
| Immunogen Target | Docking Protein 1 Phospho-Tyr362 (DOK1 pY362) |
| Isotype | IgG |
| Name | Docking Protein 1 Phospho-Tyr362 (DOK1 pY362) Antibody |
| Price | 429 |
| Provider | Abbexa |
| Purification | Purified by affinity chromatography. |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/1000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx333312 |
| Size 1 | 100 µl |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Tested Applications | ELISA, WB, IHC |
| UniProt ID | Q99704 |
Descripcion del producto en español
Background en español
Docking protein 1 (DOK1) serves as an adaptor protein involved in cellular signaling pathways, particularly those linked to tyrosine kinase receptors and cytokine receptors. DOK1 lacks intrinsic enzymatic activity but facilitates signal transduction by linking membrane-bound receptors to downstream effectors. It plays a critical role in regulating cell proliferation, differentiation, and apoptosis by acting as a negative regulator of mitogenic signaling pathways. DOK1 is highly expressed in hematopoietic cells and is instrumental in immune responses. Dysregulation of DOK1 has been implicated in oncogenesis, particularly in hematologic malignancies, where it acts as a tumor suppressor by inhibiting excessive cellular proliferation and survival signals. Its interactions with Ras-GAP and other signaling molecules underline its importance in maintaining cellular homeostasis.
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