Docking Protein 1 Phospho-Tyr362 (DOK1 pY362) Antibody
429€ (100 µl)
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Name
Docking Protein 1 Phospho-Tyr362 (DOK1 pY362) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx333312
Tested Applications
ELISA, WB, IHC
Description
DOK1 (pY362) Antibody is a Rabbit Polyclonal against DOK1 (pY362).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Docking Protein 1 Phospho-Tyr362 (DOK1 pY362) Immunogen: Peptide sequence around phosphorylation site of tyrosine 362 (P-I-Y (p)-D-E) derived from Human p62Dok. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/1000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99704 |
| Gene ID | 1796 |
| Alias | Downstream of tyrosine kinase 1,P62DOK, pp62 |
| Background | Antibody anti-DOK1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Docking protein 1 (DOK1) serves as an adaptor protein involved in cellular signaling pathways, particularly those linked to tyrosine kinase receptors and cytokine receptors. DOK1 lacks intrinsic enzymatic activity but facilitates signal transduction by linking membrane-bound receptors to downstream effectors. It plays a critical role in regulating cell proliferation, differentiation, and apoptosis by acting as a negative regulator of mitogenic signaling pathways. DOK1 is highly expressed in hematopoietic cells and is instrumental in immune responses. Dysregulation of DOK1 has been implicated in oncogenesis, particularly in hematologic malignancies, where it acts as a tumor suppressor by inhibiting excessive cellular proliferation and survival signals. Its interactions with Ras-GAP and other signaling molecules underline its importance in maintaining cellular homeostasis.
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