DNA-binding protein SATB2 (SATB2) Antibody (FITC)
260€ (50 µl)
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Name
DNA-binding protein SATB2 (SATB2) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx349643
Description
DNA-binding protein SATB2 (SATB2) Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC for the detection of Human SATB2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: DNA-binding protein SATB2 (SATB2) Immunogen: Recombinant Human DNA-binding protein SATB2 protein (228-369 AA) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by antigen affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UPW6 |
| Gene ID | 23314 |
| OMIM | 119540 |
| Alias | C2DELq32q33,DEL2Q32Q33,GLSS,Special AT-rich sequence-binding protein 2,DNA-binding protein SATB2 |
| Background | Antibody anti-SATB2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SATB homeobox 2 (SATB2) is a transcription factor that plays a crucial role in chromatin organization, gene regulation, and cellular differentiation SATB2 is involved in the regulation of skeletal development, neural differentiation, and craniofacial patterning, particularly during embryogenesis It functions by binding to specific DNA sequences and organizing chromatin into loops, facilitating the regulation of gene expression in a spatially organized manner SATB2 is highly expressed in osteoblasts and neurons, where it influences the expression of genes involved in bone formation and synaptic plasticity Mutations in SATB2 lead to developmental disorders such as SATB2-associated syndrome, which is characterized by intellectual disability, speech delays, and craniofacial abnormalities SATB2 also plays a role in cancer, where it can modulate tumor progression and metastasis through its effects on chromatin structure and gene expression Recent studies have highlighted its potential as a therapeutic target for regenerative medicine and in disorders involving disrupted bone and neural development
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