Desmoyokin (AHNAK) Antibody
364€ (100 µg)
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name
Desmoyokin (AHNAK) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230230
tested applications
ELISA, IF/ICC
Description
AHNAK Antibody is a Rabbit Polyclonal against AHNAK.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Desmoyokin (AHNAK) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IF/ICC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q09666 |
| Gene ID | 79026 |
| OMIM | 103390 |
| Alias | AHNAK1RS,PM227,AHNAK |
| Background | Antibody anti-AHNAK |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
AHNAK is a large, multifunctional nucleoprotein involved in cellular architecture, calcium signaling, and membrane repair. It is highly expressed in epithelial cells, fibroblasts, and immune cells, where it localizes to the cytoplasm, plasma membrane, and nucleus. AHNAK interacts with actin and other cytoskeletal elements, contributing to cell shape maintenance, cell migration, and membrane dynamics. It also plays a key role in calcium homeostasis by interacting with calcium channels, such as annexins and S100A10, and facilitating membrane repair processes in response to injury. AHNAK is implicated in tumor progression, particularly in cancers like glioblastoma, breast cancer, and melanoma, where its expression correlates with cell motility and invasive potential. Additionally, AHNAK has been associated with immune regulation, influencing T-cell activation and migration. Dysregulation of AHNAK contributes to cardiac hypertrophy, immune dysfunction, and cancer metastasis.
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Desmoyokin (AHNAK) Antibody
Desmoyokin (AHNAK) Antibody is a Rabbit Polyclonal against AHNAK.
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