AHNAK1 Antibody
364€ (0.1 mg)
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935106861
info@markelab.com
name
AHNAK1 Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx140148
tested applications
WB, IHC, IF/ICC, IP
Description
AHNAK1 Antibody is a Mouse Monoclonal against AHNAK1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | AHNAK1 |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | Validated in IHC-F and ICC. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | X191 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, IHC, IF/ICC, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q09666 |
| Gene ID | 79026 |
| Alias | AHNAK1RS,PM227,AHNAK |
| Background | Antibody anti-AHNAK |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
AHNAK is a large, multifunctional nucleoprotein involved in cellular architecture, calcium signaling, and membrane repair. It is highly expressed in epithelial cells, fibroblasts, and immune cells, where it localizes to the cytoplasm, plasma membrane, and nucleus. AHNAK interacts with actin and other cytoskeletal elements, contributing to cell shape maintenance, cell migration, and membrane dynamics. It also plays a key role in calcium homeostasis by interacting with calcium channels, such as annexins and S100A10, and facilitating membrane repair processes in response to injury. AHNAK is implicated in tumor progression, particularly in cancers like glioblastoma, breast cancer, and melanoma, where its expression correlates with cell motility and invasive potential. Additionally, AHNAK has been associated with immune regulation, influencing T-cell activation and migration. Dysregulation of AHNAK contributes to cardiac hypertrophy, immune dysfunction, and cancer metastasis.
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