AHNAK antibody
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935106861
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name
AHNAK antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00230
tested applications
ELISA, IF
Description
May be required for neuronal cell differentiation.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | AHNAK nucleoprotein (AHNAK) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IF: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 629 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q09666 |
| Gene ID | 79026 |
| Alias | AHNAK1RS,PM227,AHNAK |
| Background | Antibody anti-AHNAK |
| Status | RUO |
| Note | Mol. Weight 629 kDa |
Descripción
AHNAK is a large, multifunctional nucleoprotein involved in cellular architecture, calcium signaling, and membrane repair. It is highly expressed in epithelial cells, fibroblasts, and immune cells, where it localizes to the cytoplasm, plasma membrane, and nucleus. AHNAK interacts with actin and other cytoskeletal elements, contributing to cell shape maintenance, cell migration, and membrane dynamics. It also plays a key role in calcium homeostasis by interacting with calcium channels, such as annexins and S100A10, and facilitating membrane repair processes in response to injury. AHNAK is implicated in tumor progression, particularly in cancers like glioblastoma, breast cancer, and melanoma, where its expression correlates with cell motility and invasive potential. Additionally, AHNAK has been associated with immune regulation, influencing T-cell activation and migration. Dysregulation of AHNAK contributes to cardiac hypertrophy, immune dysfunction, and cancer metastasis.
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