DENN Domain-Containing Protein 2A (DENND2A) Antibody

Este producto es parte de DENND - DENN domain containing
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357.5€ (100 µg)

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935106861
info@markelab.com
name
DENN Domain-Containing Protein 2A (DENND2A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037708
tested applications
ELISA, WB, IHC

Description

Rabbit Polyclonal against the DENND2A protein.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
DENN Domain-Containing Protein 2A (DENND2A)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB, IHC
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9ULE3
Alias
FAM31D,KIAA1277
Background
Antibody anti-DENND2A
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

DENN domain containing 2A (DENND2A) is a guanine nucleotide exchange factor (GEF) that activates Rab9, a key regulator of vesicular transport between late endosomes and the trans-Golgi network. The DENN domain in DENND2A facilitates the exchange of GDP for GTP on Rab9, promoting vesicle tethering, sorting, and fusion events critical for retrograde transport. DENND2A plays an essential role in maintaining lysosomal and endosomal integrity by ensuring the proper recycling of receptors and transport of lysosomal hydrolases. This protein is vital for the degradation and recycling of membrane proteins, contributing to cellular signaling and nutrient uptake. Dysregulation of DENND2A has been implicated in lysosomal storage disorders and diseases involving defective vesicular trafficking, as its dysfunction can disrupt the balance of cargo transport and endosomal recycling. Its broad expression across tissues, combined with its role in maintaining vesicular trafficking, highlights its importance in cellular homeostasis and adaptive responses to environmental signals.
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