Delta-1-Pyrroline-5-Carboxylate Synthase (ALDH18A1) Antibody
312€ (60 µl)
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Name
Delta-1-Pyrroline-5-Carboxylate Synthase (ALDH18A1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx125513
Tested Applications
WB
Description
ALDH18A1 Antibody is a Rabbit Polyclonal against ALDH18A1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Delta-1-Pyrroline-5-Carboxylate Synthase (ALDH18A1) Immunogen: Recombinant fusion protein corresponding to human ALDH18A1 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 87 kDa Observed MW: 87 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P54886 |
| Gene ID | 5832 |
| NCBI Accession | NP_002851.2 |
| Alias | P5CS,Aldehyde dehydrogenase family 18 member A1 |
| Background | Antibody anti-ALDH18A1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALDH18A1, also known as P5CS (pyrroline-5-carboxylate synthase), is a mitochondrial enzyme that catalyzes the conversion of glutamate into pyrroline-5-carboxylate (P5C), a key step in proline and ornithine biosynthesis. This enzyme is crucial for amino acid metabolism, cellular redox balance, and collagen synthesis. ALDH18A1 is highly expressed in tissues with high metabolic activity, such as the liver, kidney, and brain. Mutations in ALDH18A1 are linked to autosomal dominant and recessive forms of P5CS deficiency, which result in hyperammonemia, intellectual disability, and connective tissue disorders due to impaired proline biosynthesis. ALDH18A1 dysfunction also contributes to neurodegenerative diseases and metabolic syndromes by disrupting amino acid metabolism and cellular stress responses. Its role in collagen synthesis makes ALDH18A1 essential for proper skin, bone, and connective tissue maintenance, and it is actively studied for its involvement in aging and fibrosis.
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