DCAF12L2 Antibody
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Description
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multi-protein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 9. However, the CDS of this intronless gene remains intact, it is conserved in other mammalian species, it is known to be transcribed, and it is therefore thought to encode a functional protein.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DCAF12L2 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5VW00 |
| Alias | WDR40C,WD repeat-containing protein 40C |
| Background | Antibody anti-DCAF12L2 |
| Status | RUO |
Descripción
DDB1 and CUL4 associated factor 12 like 2 (DCAF12L2) is another member of the DCAF12 family, characterized by WD40 repeats that are critical for interactions with the CUL4-DDB1 complex and substrate recognition. Although little is known about DCAF12L2, its expression pattern indicates potential involvement in reproductive biology, particularly in germ cells, as well as general protein homeostasis in various tissues. Evolutionary studies have revealed events such as intronization in the DCAF12L2 gene, suggesting that this paralog has developed distinct functions compared to DCAF12 and DCAF12L1. These changes may relate to specialized mechanisms of protein regulation that allow functional diversification in different cellular contexts. While further studies are required to identify its substrates and exact functions, DCAF12L2 is a promising target for investigating the regulation of ubiquitination and its impact on cellular homeostasis and protein function.
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