DAPP1 Cell ELISA Kit
513.5€ (96 tests)
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name
DAPP1 Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595172
tested applications
ELISA
Description
DAPP1 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | DAPP1 |
| Reactivity | Human, Mouse |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9UN19 |
| Gene ID | 27071 |
| OMIM | 605768 |
| Alias | DAPP1, BAM32,B lymphocyte adapter protein Bam32 |
| Background | Elisa kits for DAPP1 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
DAPP1 (Dual Adapter for Phosphotyrosine and 3-Phosphoinositide) is a multifunctional adaptor protein involved in the regulation of cellular signaling pathways. It contains both SH2 (Src Homology 2) and PH (Pleckstrin Homology) domains, which allow it to interact with phosphorylated tyrosine residues and phosphoinositides, respectively. These interactions make DAPP1 a key player in the regulation of various cellular processes, including signal transduction, immune responses, and actin cytoskeleton remodeling. DAPP1 is especially important in immune cells, where it participates in the regulation of B cell receptor (BCR) signaling. Upon BCR activation, DAPP1 translocates to the plasma membrane and helps coordinate downstream signaling events that control cell survival, differentiation, and proliferation. It plays a role in modulating cell motility and the immune synapse, contributing to efficient immune responses. DAPP1 is also involved in the regulation of intracellular calcium signaling, which is crucial for processes like cell activation and communication. Its function is tightly regulated, and alterations in DAPP1 expression or activity can lead to immune dysfunction and have been implicated in various diseases, including cancer and autoimmune disorders.
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