Cytosolic Carboxypeptidase 6 (AGBL4) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Cytosolic Carboxypeptidase 6 (AGBL4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx014414
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against AGBL4 protein. Immunogen region is C-terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cytosolic Carboxypeptidase 6 (AGBL4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5VU57 |
| Alias | CCP6 |
| Background | Antibody anti-AGBL4 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
AGBL4 is an enzyme involved in the deglutamylation of tubulin, a critical process for regulating microtubule dynamics and stability. It removes polyglutamate side chains from the C-terminal tails of tubulin, thereby influencing microtubule-based transport, axon guidance, and neuronal plasticity. AGBL4 is expressed in various tissues, including the brain, heart, and skeletal muscle, suggesting a role in both neuronal and muscular function. Dysregulation of AGBL4 has been associated with neurological disorders, where defective tubulin modifications impair intracellular transport, leading to synaptic dysfunction and neurodegeneration. Emerging research also implicates AGBL4 in certain cancers, where altered microtubule stability can drive aberrant cell division and migration. The enzyme’s activity is crucial for maintaining the delicate balance of tubulin modifications required for normal cellular and tissue homeostasis.
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