Cytosolic Carboxypeptidase 5 (AGBL5) Antibody
292.5€ (80 µl)
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935106861
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name
Cytosolic Carboxypeptidase 5 (AGBL5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx026443
tested applications
ELISA, WB, IHC, IF/ICC
Description
AGBL5 has a function in the processing of cytosolic proteins such as alpha tubulin, which is known to be modified by the removal of a C terminal tyrosine. It is expressed in the brain. There are three named isoforms.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cytosolic Carboxypeptidase 5 (AGBL5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8NDL9 |
| Alias | CCP5,RP75 |
| Background | Antibody anti-AGBL5 |
| Status | RUO |
Descripción
AGBL5 functions as a tubulin deglutamylase, removing polyglutamate chains from the tails of microtubules to regulate their dynamics and functionality. It is predominantly expressed in the nervous system but is also present in other tissues, where it plays a role in axon development, neuronal signaling, and intracellular transport mechanisms. AGBL5 activity is essential for proper mitotic spindle formation, ensuring accurate chromosome segregation during cell division. Dysregulation of AGBL5 has been linked to neurodegenerative diseases, such as Alzheimer’s disease, due to the accumulation of hyperglutamylated tubulin that disrupts axonal transport. It has also been implicated in cancer progression, where alterations in microtubule dynamics can enhance cell motility and invasive potential. Further studies are ongoing to elucidate its broader physiological and pathological roles.
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