Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Antibody
221€ (50 µg)
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Name
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx328954
Tested Applications
ELISA, WB, IHC
Description
CFTR Antibody is a Rabbit Polyclonal against CFTR.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Immunogen: Synthesized peptide derived from human CFTR around the non-phosphorylation site of S737. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/5000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P13569 |
| Gene ID | 1080 |
| Alias | ATP-binding cassette sub-family C member 7,CF,MRP7,ABC35,ABCC7,CFTR/MRP,TNR-CFTR,dJ760C5.1,Cystic fibrosis transmembrane conductance regulator,Channel conductance-controlling ATPase |
| Background | Antibody anti-CFTR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CF Transmembrane Conductance Regulator (ABCC7), widely known as the cystic fibrosis transmembrane conductance regulator (CFTR), is a chloride channel essential for maintaining ion and water balance across epithelial cell membranes. Mutations in the CFTR gene cause cystic fibrosis (CF), a life-threatening genetic disorder that leads to thick mucus buildup in the lungs, pancreas, and other organs. As an ATP-gated channel, ABCC7 regulates chloride and bicarbonate secretion, influencing fluid viscosity and pH in various tissues. Beyond ion transport, CFTR modulates inflammation and immune responses, contributing to its broader physiological significance. Therapeutic interventions targeting CFTR, such as small-molecule modulators, have revolutionized CF management, improving lung function and quality of life for many patients. Additionally, CFTR dysfunction has been implicated in other conditions like chronic obstructive pulmonary disease (COPD) and pancreatitis, underlining its relevance in diverse respiratory and gastrointestinal diseases.
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