Cow Tissue Factor Pathway Inhibitor 2 (TFPI2) Protein
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935106861
info@markelab.com
Precio
468€ (50 µg)
Protein TFPI2
proveedor
Abbexareference
abx069327Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant TFPI2 is a recombinant Cow protein produced in a Prokaryotic expression system (E. coli).
Background
Tissue Factor Pathway Inhibitor 2 (TFPI2), another Kunitz-type inhibitor, is structurally similar to TFPI but exhibits distinct functions, primarily inhibiting plasmin and matrix metalloproteinases (MMPs). TFPI2 plays a critical role in modulating extracellular matrix degradation, cell migration, and angiogenesis, influencing processes like wound healing, tissue remodeling, and tumor progression. Unlike TFPI, TFPI2 is broadly expressed in various tissues and is frequently downregulated in cancers, where its loss contributes to tumor invasion, metastasis, and angiogenesis. Its epigenetic silencing through promoter hypermethylation is a hallmark in several malignancies, highlighting its potential as a tumor suppressor and biomarker for cancer diagnosis and prognosis.
Características del producto
category
Proteins and Peptides
origin
Cow
host
E. coli
immunogen target
Tissue Factor Pathway Inhibitor 2 (TFPI2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
50 µg
size 2
100 µg
size 3
200 µg
size 4
500 µg
size 5
1 mg
observerd MW
Molecular Weight: Calculated MW: 25.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp23-Phe234 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TFPI2
dry ice
No
availability
Shipped within 5-7 working days.
alias
PP5,REF1,TFPI-2,Placental protein 5
NCBI accession
NP_001119574
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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