Cow Proteinase-Activated Receptor 2 / PAR2 (F2RL1) ELISA Kit

Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for F2RL1
proveedor
Abbexareference
abx519156Tested Applications
ELISAreactivity
Cowstatus
RUOclonality
Descripción
Cow Proteinase-Activated Receptor 2 / PAR2 (F2RL1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Cow Proteinase-Activated Receptor 2 / PAR2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Proteinase-Activated Receptor 2 (F2RL1), also known as PAR2, is a G protein-coupled receptor (GPCR) activated by the cleavage of its N-terminal domain by serine proteases, such as trypsin and mast cell tryptase. PAR2 is widely expressed in various tissues, including endothelial cells, platelets, smooth muscle, and immune cells, where it regulates inflammatory responses, cell migration, and pain perception. Upon activation, F2RL1 couples to Gq, Gi, and G12/13 proteins, stimulating phospholipase C (PLC), MAPK, and Rho signaling pathways. These pathways lead to increased intracellular calcium, cell contraction, and gene expression associated with inflammation. F2RL1 plays a role in immune cell recruitment during allergic reactions, wound healing, and tissue remodeling. Dysregulation of F2RL1 has been implicated in inflammatory diseases, cancer metastasis, and pain disorders. PAR2 antagonists are being developed for therapeutic applications in conditions like asthma, chronic pain, and cancer, by modulating its pro-inflammatory effects and enhancing tissue repair.
Características del producto
category
ELISA Kits
immunogen target
Proteinase-Activated Receptor 2 / PAR2 (F2RL1)
reactivity
Cow
test range
78 pg/ml - 5000 pg/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
F2RL1,GPR11,coagulation factor II receptor-like 1,Protease-activated receptor-2 ,thrombin receptor-like 1,PAR2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
F2RL1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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