Coronin 7 (CORO7) Antibody
169€ (20 µg)
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name
Coronin 7 (CORO7) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx303472
tested applications
ELISA
Description
CORO7 Antibody is a Rabbit Polyclonal against CORO7.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Coronin 7 (CORO7) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P57737 |
| Gene ID | 79585 |
| NCBI Accession | NP_001188401.1, NM_001201472.1, NP_001188402.1, NM_001201473.1, NP_078811.3, NM_024535.4 |
| OMIM | 611668 |
| Alias | CRN7,POD1,70 kDa WD repeat tumor rejection antigen homolog,Coronin-7 |
| Background | Antibody anti-CORO7 |
| Status | RUO |
Descripción
Coronin 7 (CORO7) is a member of the coronin protein family, distinguished by its lack of actin-binding capability, unlike other coronins. Instead, it functions as an F-actin regulator involved in directing anterograde transport from the Golgi apparatus to endosomes. CORO7 localizes to the trans-Golgi network and is essential for maintaining Golgi apparatus morphology. Its recruitment to Golgi membranes requires Src kinase activity and the integrity of the AP-1 adaptor protein complex. CORO7 interacts with the μ1-subunit of AP-1 via a tyrosine-288-based sorting signal and is phosphorylated by Src kinase, which is crucial for its membrane targeting. Additionally, CORO7 undergoes K33-linked polyubiquitination via an E3 ligase complex, influencing its function in Golgi trafficking. Notably, CORO7 does not interact with actin or participate in actin-mediated processes but plays a significant role in vesicular trafficking pathways.
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