Contactin 1 (CNTN1) Antibody
780€ (1 ml)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Contactin 1 (CNTN1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx171916
tested applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Contactin 1 (CNTN1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | F3,GP135,MYPCN,CMYP12,Neural cell surface protein F3,Glycoprotein gp135,Contactin-1 |
| Background | Antibody anti-CNTN1 |
| Status | RUO |
Descripción
Contactin 1 (CNTN1) is a neuronal cell adhesion molecule belonging to the immunoglobulin superfamily, playing a crucial role in nervous system development and maintenance. CNTN1 is a glycosylphosphatidylinositol (GPI)-anchored protein predominantly expressed in neurons, where it mediates axon guidance, neuronal migration, and synaptic formation. It interacts with other cell surface receptors such as the Notch and amyloid precursor protein (APP) signaling pathways, influencing neuronal differentiation and axon pathfinding. CNTN1 is also involved in the formation and stabilization of paranodal junctions in myelinated nerves by binding to Caspr and neurofascin, ensuring proper saltatory conduction. Dysregulation of CNTN1 has been implicated in neurodevelopmental disorders such as autism spectrum disorders (ASD) and intellectual disabilities, as well as in autoimmune neuropathies like chronic inflammatory demyelinating polyneuropathy (CIDP). It has also been linked to cancer metastasis, with elevated levels associated with poor prognosis in certain tumors. Its extracellular immunoglobulin-like and fibronectin type III domains mediate homophilic and heterophilic interactions, making it an essential player in neuronal connectivity and signaling.
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