Collagen Type XVIII Alpha 1 (COL18A1) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
COL18A1 Antibody is a Rabbit Polyclonal antibody against COL18A1. This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Collagen Type XVIII Alpha 1 (COL18A1) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P39060 |
| Gene ID | 80781 |
| NCBI Accession | NP_085059.2 |
| Background | Antibody anti-COL18A1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Related Products
COL18A1 antibody
Endostatin is a naturally-occurring 20-kDa C-terminal fragment derived from COL18A1(also named as KNO). It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. It potently inhibits endothelial cell proliferation and inhibits endothelial cell angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. Endostatin is a broad spectrum angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor(bFGF/FGF-2) and vascular endothelial growth factor(VEGF).
Ver Producto
Collagen Type XVIII Alpha 1 (COL18A1) Antibody
COL18A1 Antibody is a Rabbit Polyclonal antibody against COL18A1. This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
Ver Producto
Collagen Type XVIII Alpha 1 (COL18A1) Antibody
Rabbit polyclonal antibody against COL18A1 protein. Immunogen region is C-terminal.
Ver Producto