Class E Basic Helix-Loop-Helix Protein 41 (BHLHE41) Antibody

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Description
BHLHE41 Antibody is a Rabbit Polyclonal against BHLHE41.
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | Class E Basic Helix-Loop-Helix Protein 41 (BHLHE41) |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Recommended Dilution | WB: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purity | ≥ 95% (SDS-PAGE) |
Purification | Purified by immunogen affinity chromatography. |
Size 1 | 100 µg |
Form | Liquid |
Tested Applications | ELISA, WB |
Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
Availability | Shipped within 5-12 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q9C0J9 |
Gene ID | 79365 |
OMIM | 606200 |
Background | Antibody anti-BHLHE41 |
Status | RUO |
Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
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Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop(DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors(PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements(5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.
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