Class E Basic Helix-Loop-Helix Protein 41 (BHLHE41) Antibody
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Description
Basic Helix-Loop-Helix Family, Member E41 Antibody is a Rabbit Polyclonal antibody against Basic Helix-Loop-Helix Family, Member E41.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Class E Basic Helix-Loop-Helix Protein 41 (BHLHE41) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9C0J9 |
| Gene ID | 79365 |
| OMIM | 606200 |
| Background | Antibody anti-BHLHE41 |
| Status | RUO |
Descripción
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BHLHE41 antibody
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop(DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors(PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements(5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.
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Recombinant Human BHLHE41
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Class E Basic Helix-Loop-Helix Protein 41 (BHLHE41) Antibody
Basic Helix-Loop-Helix Family, Member E41 Antibody is a Rabbit Polyclonal antibody against Basic Helix-Loop-Helix Family, Member E41.
Ver Producto