Chemokine C-X-C-Motif Receptor 7 (CXCR7) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Chemokine C-X-C-Motif Receptor 7 (CXCR7) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx034098
tested applications
ELISA, WB, IHC
Description
CXCR7 is a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Chemokine C-X-C-Motif Receptor 7 (CXCR7) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P25106 |
| Alias | chemokine (C-X-C motif) receptor 7,chemokine orphan receptor 1,CXCR7,Cxcr7,GPR159 ,G-protein coupled receptor 159,RDC-1,RDC1,CMKOR2 |
| Background | Antibody anti-ACKR3 |
| Status | RUO |
Descripción
ACKR3, also known as CXCR7, is an atypical chemokine receptor that binds CXCL12 and CXCL11 but does not trigger classical G protein signaling. Instead, it functions as a "scavenger receptor," internalizing and degrading chemokines to regulate their extracellular levels. ACKR3 is expressed on endothelial cells, smooth muscle cells, and cancer cells and plays a critical role in modulating chemokine gradients, which control immune cell migration. In cancer, ACKR3 is frequently overexpressed and promotes tumor growth, survival, and metastasis by scavenging CXCL12, enhancing CXCR4-mediated signaling. It is involved in glioblastoma, breast, and prostate cancers, where its expression correlates with poor prognosis and therapy resistance. ACKR3 also contributes to angiogenesis by promoting endothelial cell migration and tube formation. In the central nervous system, it regulates CXCL12 availability, impacting neurogenesis and neuronal repair. While it does not induce typical signaling, ACKR3 activates β-arrestin-dependent pathways that influence cellular adhesion, survival, and proliferation. Its atypical signaling and scavenging activity make ACKR3 an attractive target for cancer therapy and inflammatory disease treatment.
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