Cell Division Cycle 26 (CDC26) Antibody
364€ (100 µg)
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935106861
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name
Cell Division Cycle 26 (CDC26) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx231524
tested applications
ELISA, WB, IHC
Description
CDC26 Antibody is a Rabbit Polyclonal against CDC26.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cell Division Cycle 26 (CDC26) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8NHZ8 |
| Gene ID | 246184 |
| OMIM | 614533 |
| Alias | CDC26, ANAPC12, C9orf17 |
| Background | Antibody anti-CDC26 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ANAPC12 (CDC26)is a structural subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) that stabilizes the assembly of the complex and supports its ubiquitin ligase activity. ANAPC12 forms part of the platform that anchors other key components, ensuring the recruitment and interaction of co-activators such as CDC20 and CDH1 with substrates. Through its structural role, ANAPC12 helps mediate the ubiquitination of critical regulators such as cyclins, securin, and other proteins involved in cell cycle progression. ANAPC12 is required for proper activation of APC/C during metaphase-to-anaphase transition and mitotic exit. Dysregulation of ANAPC12 can impair APC/C activity, leading to mitotic defects, genomic instability, and increased susceptibility to cancer. Recent studies suggest that ANAPC12 may play additional roles in cellular stress responses and DNA damage repair, linking it to broader regulatory networks. Its importance in APC/C function highlights ANAPC12 as a critical factor for maintaining cell cycle fidelity and genomic integrity.
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