Tyrosine-Protein Kinase Mer (MERTK) Antibody
286€ (100 µl)
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935106861
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name
Tyrosine-Protein Kinase Mer (MERTK) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx128436
tested applications
WB, IHC, IF/ICC
Description
Tyrosine-Protein Kinase Mer Antibody is a Rabbit Polyclonal against Tyrosine-Protein Kinase Mer.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tyrosine-Protein Kinase Mer (MERTK) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q12866 |
| Gene ID | 10461 |
| NCBI Accession | NP_006334.2 |
| OMIM | 604705 |
| Alias | MER,RP38,c-Eyk,c-mer,Tyro12,Receptor tyrosine kinase MerTK,Proto-oncogene c-Mer |
| Background | Antibody anti-MERTK |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
MERTK (MER Proto-Oncogene, Tyrosine Kinase) is a member of the TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinase family, which plays a crucial role in the regulation of immune response, cell survival, migration, and phagocytosis. This gene was identified due to its homology with the avian oncogene v-Mer and is involved in the clearance of apoptotic cells and immune tolerance. The MERTK protein is primarily expressed in macrophages, dendritic cells, and retinal pigment epithelial cells. Dysregulation of MERTK has been implicated in various diseases, including cancer, autoimmune disorders, and retinal degenerative diseases.
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