BTB/POZ Domain-Containing Protein KCTD16 (KCTD16) Antibody

Este producto es parte de KCTD - BTB/POZ domain-containing protein
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357.5€ (100 µg)

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935106861
info@markelab.com
name
BTB/POZ Domain-Containing Protein KCTD16 (KCTD16) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037183
tested applications
ELISA, WB

Description

Rabbit Polyclonal against the KCTD16 protein.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
BTB/POZ Domain-Containing Protein KCTD16 (KCTD16)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
KCTD16
Background
Antibody anti-KCTD16
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

KCTD16 is another member of the KCTD family that functions as an auxiliary subunit of GABA-B receptors, modulating their pharmacological and signaling properties. KCTD16 specifically regulates the kinetics of GABA-B receptor activation and desensitization, influencing inhibitory neurotransmission in the central nervous system. It is widely expressed in brain regions associated with cognition, motor activity, and emotional regulation, playing a role in synaptic plasticity and neuronal excitability. KCTD16 interacts with GABA-B receptor subunits to enhance receptor sensitivity and prolong inhibitory signaling, which is critical for maintaining neural network stability. Dysregulation of KCTD16 has been linked to psychiatric disorders, including schizophrenia, anxiety, and depression, where impaired GABA-B receptor function contributes to disrupted inhibitory signaling. Beyond the nervous system, KCTD16 may participate in protein degradation pathways through its BTB/POZ domain, influencing cellular homeostasis. Its ability to fine-tune GABA-B receptor signaling positions KCTD16 as a key target for therapeutic interventions aimed at restoring inhibitory balance in neurological and psychiatric disorders.
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