BRCA1-Associated RING Domain Protein 1 (BARD1) Antibody
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Description
BRCA1-Associated RING Domain Protein 1 (BARD1) Antibody is a Rabbit Polyclonal antibody for the detection of DMC1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | BRCA1-Associated RING Domain Protein 1 (BARD1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14565 |
| Gene ID | 11144 |
| OMIM | 602721 |
| Background | Antibody anti-BARD1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
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anti- BARD1 antibody
Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
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BRCA1-Associated RING Domain Protein 1 (BARD1) Antibody
BARD1 Antibody is a Rabbit Polyclonal Antibody against BARD1.
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BRCA1-Associated RING Domain Protein 1 (BARD1) Antibody
BRCA1-Associated RING Domain Protein 1 (BARD1) Antibody is a Rabbit Polyclonal antibody for the detection of DMC1.
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