BARD1 antibody

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935106861
info@markelab.com
name
BARD1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00803
tested applications
ELISA, WB

Description

Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
BRCA1 associated RING domain 1 (BARD1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1:500-1:1000
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
90-100 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q99728
Gene ID
580
Alias
BRCA1-associated RING domain protein 1 (BARD-1),RING-type E3 ubiquitin transferase BARD1,BARD1
Background
Antibody anti-BARD1
Status
RUO
Note
Mol. Weight 90-100 kDa

Descripción

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