anti- BARD1 antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | BRCA1 associated RING domain 1 |
| Host | Rabbit |
| Reactivity | human |
| Recommended Dilution | WB: 1:500-1:1000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 90-100 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q99728 |
| Gene ID | 580 |
| Alias | BARD 1, BARD1, BRCA1 associated RING domain 1 |
| Background | Antibody anti-BARD1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Related Products
anti- BARD1 antibody
Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
Ver Producto
BRCA1-Associated RING Domain Protein 1 (BARD1) Antibody
BARD1 Antibody is a Rabbit Polyclonal Antibody against BARD1.
Ver Producto
BRCA1-Associated RING Domain Protein 1 (BARD1) Antibody
BRCA1-Associated RING Domain Protein 1 (BARD1) Antibody is a Rabbit Polyclonal antibody for the detection of DMC1.
Ver Producto