Brain Specific Angiogenesis Inhibitor 3 / BAI3 (ADGRB3) Antibody
312€ (50 µl)
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935106861
info@markelab.com
name
Brain Specific Angiogenesis Inhibitor 3 / BAI3 (ADGRB3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx148536
tested applications
WB
Description
Brain Specific Angiogenesis Inhibitor 3 / BAI3 (ADGRB3) Antibody is a Rabbit Polyclonal against ADGRB3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Brain Specific Angiogenesis Inhibitor 3 / BAI3 (ADGRB3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000 - 1/3000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography using epitope-specific peptide. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60242 |
| Gene ID | 577 |
| Alias | ADGRB3,BAI3 |
| Background | Antibody anti-ADGRB3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ADGRB3, known as BAI3, is a GPCR highly expressed in the brain, where it regulates synaptic development and neuronal connectivity. It plays a role in dendritic arborization and synapse formation, supporting neuronal circuitry and communication. ADGRB3 interacts with proteins involved in synaptic organization and phagocytosis, contributing to the removal of apoptotic neurons and cellular debris. Dysregulation of ADGRB3 has been associated with autism spectrum disorders and other neurodevelopmental conditions due to its role in synaptic refinement. Additionally, it is implicated in vascular homeostasis, although its angiogenic functions are less defined compared to ADGRB1. ADGRB3’s dual involvement in synaptic and vascular processes highlights its importance in neurovascular coupling and overall brain health.
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