Brain Specific Angiogenesis Inhibitor 1 / BAI1 (ADGRB1) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
Brain Specific Angiogenesis Inhibitor 1 / BAI1 (ADGRB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx326074
tested applications
ELISA, WB, IHC, IF/ICC
Description
Brain Specific Angiogenesis Inhibitor 1 / BAI1 (ADGRB1) Antibody is a Rabbit Polyclonal against Brain Specific Angiogenesis Inhibitor 1 / BAI1 (ADGRB1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Brain Specific Angiogenesis Inhibitor 1 / BAI1 (ADGRB1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14514 |
| Gene ID | 575 |
| Alias | ADGRB1,BAI1,GDAIF |
| Background | Antibody anti-ADGRB1 |
| Status | RUO |
Descripción
ADGRB1, also known as BAI1 (Brain-Specific Angiogenesis Inhibitor 1), is a member of the adhesion G protein-coupled receptor (GPCR) family predominantly expressed in the brain. It plays a critical role in inhibiting angiogenesis, promoting synaptic plasticity, and mediating phagocytic clearance of apoptotic cells and pathogens. Structurally, ADGRB1 contains multiple extracellular domains that facilitate interactions with matrix proteins and apoptotic cell markers. Dysregulation of ADGRB1 is associated with glioblastoma, as it suppresses tumor angiogenesis and growth, and its loss can contribute to tumor progression. Additionally, it has been implicated in synaptic function and neuronal health, with potential roles in neurodevelopmental disorders and neurodegeneration. ADGRB1’s ability to link extracellular signals to intracellular pathways highlights its importance in vascular regulation and brain function.
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