Brain Specific Angiogenesis Inhibitor 1 / BAI1 (ADGRB1) Antibody

Este producto es parte de ADGRB - Adhesion G protein-coupled receptor B
Product Graph
52€ (10 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Brain Specific Angiogenesis Inhibitor 1 / BAI1 (ADGRB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015270
tested applications
ELISA, WB, IHC, IF/ICC

Description

Rabbit polyclonal antibody against Brain Specific Angiogenesis Inhibitor 1 / BAI1 (ADGRB1) protein. Immunogen region is Internal.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Brain Specific Angiogenesis Inhibitor 1 / BAI1 (ADGRB1)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/500 - 1/3000, IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/500, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
Size 1
10 µg
Size 2
100 µg
Size 3
200 µg
Size 4
300 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF/ICC
Buffer
PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O14514
Alias
ADGRB1,BAI1,GDAIF
Background
Antibody anti-ADGRB1
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

ADGRB1, also known as BAI1 (Brain-Specific Angiogenesis Inhibitor 1), is a member of the adhesion G protein-coupled receptor (GPCR) family predominantly expressed in the brain. It plays a critical role in inhibiting angiogenesis, promoting synaptic plasticity, and mediating phagocytic clearance of apoptotic cells and pathogens. Structurally, ADGRB1 contains multiple extracellular domains that facilitate interactions with matrix proteins and apoptotic cell markers. Dysregulation of ADGRB1 is associated with glioblastoma, as it suppresses tumor angiogenesis and growth, and its loss can contribute to tumor progression. Additionally, it has been implicated in synaptic function and neuronal health, with potential roles in neurodevelopmental disorders and neurodegeneration. ADGRB1’s ability to link extracellular signals to intracellular pathways highlights its importance in vascular regulation and brain function.

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