Brain Specific Angiogenesis Inhibitor 1 / BAI1 (ADGRB1) Antibody

Este producto es parte de ADGRB - Adhesion G protein-coupled receptor B
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260€ (50 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Brain Specific Angiogenesis Inhibitor 1 / BAI1 (ADGRB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx212955
tested applications
ELISA, IHC

Description

Brain Specific Angiogenesis Inhibitor 1 / BAI1 (ADGRB1) Antibody is a Rabbit Polyclonal against Brain Specific Angiogenesis Inhibitor 1 / BAI1 (ADGRB1).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Brain Specific Angiogenesis Inhibitor 1 / BAI1 (ADGRB1)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
ELISA: 1/2000 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Antigen Affinity Chromatography.
Size 1
50 µl
Size 2
100 µl
Form
Liquid
Tested Applications
ELISA, IHC
Buffer
PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O14514
Gene ID
575
Alias
ADGRB1,BAI1,GDAIF
Background
Antibody anti-ADGRB1
Status
RUO

Descripción

ADGRB1, also known as BAI1 (Brain-Specific Angiogenesis Inhibitor 1), is a member of the adhesion G protein-coupled receptor (GPCR) family predominantly expressed in the brain. It plays a critical role in inhibiting angiogenesis, promoting synaptic plasticity, and mediating phagocytic clearance of apoptotic cells and pathogens. Structurally, ADGRB1 contains multiple extracellular domains that facilitate interactions with matrix proteins and apoptotic cell markers. Dysregulation of ADGRB1 is associated with glioblastoma, as it suppresses tumor angiogenesis and growth, and its loss can contribute to tumor progression. Additionally, it has been implicated in synaptic function and neuronal health, with potential roles in neurodevelopmental disorders and neurodegeneration. ADGRB1’s ability to link extracellular signals to intracellular pathways highlights its importance in vascular regulation and brain function.

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