Bile Salt Export Pump (ABCB11) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Bile Salt Export Pump (ABCB11) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx147866
tested applications
ELISA, IHC
Description
Bile Salt Export Pump (ABCB11) Antibody is a Rabbit Polyclonal antibody for the detection of BSEP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Bile Salt Export Pump (ABCB11) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95342 |
| Gene ID | 8647 |
| OMIM | 601847 |
| Alias | ABCB11,ABC16,BRIC2,BSEP,PFIC-2,PFIC2,PGY4,SPGP |
| Background | Antibody anti-ABCB11 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ABCB11, also known as the bile salt export pump (BSEP), is an essential transporter located on the canalicular membrane of hepatocytes. It is responsible for exporting bile salts from the liver into bile, a critical step in the digestion and absorption of dietary fats and the excretion of waste products. ABCB11 is ATP-dependent and plays a vital role in maintaining bile flow and preventing bile salt accumulation, which can damage liver cells. Mutations in the ABCB11 gene are associated with progressive familial intrahepatic cholestasis type 2 (PFIC2), a severe liver disorder characterized by impaired bile salt secretion and liver damage. Dysregulation or inhibition of ABCB11 is also implicated in drug-induced cholestasis and liver injury. Its essential function in bile production and liver health makes it a critical target for understanding and treating cholestatic diseases.
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