Bik BH3 Domain Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
The Bik protein is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programmed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Bik BH3 Domain |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/2000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13323 |
| NCBI Accession | NP_001188.1 |
| Alias | BIP1,BP4,NBK,Apoptosis inducer NBK |
| Background | Antibody anti-BIK |
| Status | RUO |
Descripción
BIK is a pro-apoptotic member of the BCL-2 family that promotes programmed cell death by interacting with anti-apoptotic proteins, such as BCL-2 and BCL-XL, and neutralizing their function. BIK functions in the intrinsic apoptotic pathway, where it localizes to the mitochondria and induces mitochondrial outer membrane permeabilization (MOMP), leading to cytochrome c release and caspase activation. It acts as a BH3-only protein, a subclass of BCL-2 family proteins that serve as stress sensors for cellular damage, DNA replication errors, and oncogenic signaling. BIK is transcriptionally regulated by p53 and is involved in eliminating damaged or transformed cells, thus functioning as a tumor suppressor. BIK is often downregulated or silenced in cancers, where its loss contributes to apoptosis resistance, cell survival, and tumor progression. Overexpression studies show enhanced cell death, whereas knockdown studies reveal reduced apoptosis and increased tumor cell survival, highlighting BIK’s essential role in apoptosis induction, tumor suppression, and cellular stress responses.
Related Products
Bik BH3 Domain Antibody
The Bik protein is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programmed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.
Ver Producto
Bik (pT33) Antibody
The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.
Ver Producto