BIK - BCL2 Interacting Killer | Elisa - Clia - Antibody - Protein

Family main features

Background

BCL2 Interacting Killer (BIK), also known as NBK (Nineteen-kilodalton Bcl-2-interacting Killer), is a pro-apoptotic protein that belongs to the Bcl-2 family. The Bcl-2 family of proteins plays a pivotal role in the regulation of apoptosis, with members classified into anti-apoptotic and pro-apoptotic groups based on their function. BIK, identified through its interaction with Bcl-2, is known to promote apoptosis by antagonizing the function of anti-apoptotic proteins like Bcl-2 and Bcl-XL. Its expression is regulated by various stimuli, including DNA damage, oncogene activation, and growth factor deprivation.


Protein Structure

BIK is characterized by several structural features typical of Bcl-2 family proteins:

  • BH3 Domain: The BH3 (Bcl-2 homology 3) domain is crucial for its pro-apoptotic function, allowing BIK to interact with and neutralize anti-apoptotic Bcl-2 family members.
  • Hydrophobic C-Terminus: This region helps BIK anchor to intracellular membranes, particularly the mitochondria and endoplasmic reticulum (ER), where it exerts its pro-apoptotic effects.
  • N-Terminal Domain: Contains sites for post-translational modifications, such as phosphorylation, which can regulate BIK's activity and stability.


Classification and Subtypes

BIK is classified as a BH3-only protein within the Bcl-2 family, which includes other pro-apoptotic proteins such as BID, BAD, and NOXA. These proteins share the BH3 domain but lack other Bcl-2 homology domains found in multi-domain pro-apoptotic proteins like BAX and BAK.


Function and Biological Significance

BIK plays a significant role in promoting apoptosis through several mechanisms:

  • Mitochondrial Pathway Activation: BIK induces mitochondrial outer membrane permeabilization (MOMP), leading to the release of cytochrome c and subsequent activation of caspases, which are essential for the execution phase of apoptosis.
  • ER Stress and Apoptosis: BIK can localize to the ER and contribute to apoptosis in response to ER stress by modulating calcium homeostasis and interacting with other apoptotic regulators.
  • Interaction with Anti-Apoptotic Proteins: BIK binds to anti-apoptotic proteins like Bcl-2 and Bcl-XL through its BH3 domain, inhibiting their function and promoting cell death.


Clinical Issues

  • Cancer: Dysregulation of apoptosis is a hallmark of cancer, and alterations in the expression or function of BIK can contribute to tumorigenesis. In some cancers, BIK expression is downregulated or its apoptotic function is inhibited, allowing cancer cells to evade programmed cell death.
  • Therapeutic Potential: Restoring BIK function or mimicking its activity with BH3 mimetics represents a potential therapeutic strategy for inducing apoptosis in cancer cells resistant to conventional therapies.
  • Drug Resistance: Some studies suggest that BIK may be involved in the sensitivity of cancer cells to chemotherapeutic agents, making it a potential marker for predicting treatment response.


Summary

BIK (BCL2 Interacting Killer) is a pro-apoptotic BH3-only protein that plays a critical role in regulating apoptosis. By antagonizing anti-apoptotic Bcl-2 family members and promoting mitochondrial dysfunction, BIK is essential for programmed cell death in response to various cellular stresses. Its dysregulation is implicated in cancer progression and resistance to therapy, highlighting its potential as a target for cancer treatment. Understanding the precise mechanisms by which BIK induces apoptosis and its interactions with other apoptotic regulators is crucial for developing novel therapeutic approaches to enhance cell death in cancerous cells.



BIK Recommended name:

BCL2 Interacting Killer (BIK)

Aliases for BIK

BIP1,BP4,NBK,Apoptosis inducer NBK

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con BIK - BCL2 Interacting Killer

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaBIKabx595063BIK Cell ELISA KitHumanCell ELISA493.7596 testsQ13323RUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
AbbexaBIKabx324388BCL2 Interacting Killer Phospho-Thr33 (BIK pT33) AntibodyHumanPolyclonalRabbitBCL2 Interacting Killer Phospho-Thr33 (BIK pT33)UnconjugatedELISA, WB, IHC187.550 µgQ13323RUO
AbbexaBIKabx001932Bcl-2-Interacting Killer (BIK) AntibodyHumanPolyclonalRabbitBcl-2-Interacting Killer (BIK)UnconjugatedWB17520 µlQ13323RUO
AbbexaBIKabx320215Bcl-2-Interacting Killer (BIK) AntibodyHumanPolyclonalRabbitBcl-2-Interacting Killer (BIK)UnconjugatedELISA, IHC237.550 µlQ13323RUO
AbbexaBIKabx411860Bcl-2-Interacting Killer (BIK) AntibodyHumanPolyclonalRabbitBcl-2-Interacting Killer (BIK)UnconjugatedWB, IHC437.5100 µgQ13323RUO
AbbexaBIKabx027273Bik BH3 Domain AntibodyHumanPolyclonalRabbitBik BH3 DomainUnconjugatedELISA, WB, IHC281.2580 µlQ13323RUO
AbbexaBIKabx324775BCL2 Interacting Killer (BIK) AntibodyHumanPolyclonalRabbitBCL2 Interacting Killer (BIK)UnconjugatedELISA, WB, IHC, IF/ICC187.550 µgQ13323RUO
AbbexaBIKabx332949BCL2 Interacting Killer Phospho-Thr33 (BIK pT33) AntibodyHumanPolyclonalRabbitBCL2 Interacting Killer Phospho-Thr33 (BIK pT33)UnconjugatedELISA, WB, IHC412.5100 µlQ13323RUO
AbbexaBIKabx031835Bik (pT33) AntibodyHumanPolyclonalRabbitBik (pT33)UnconjugatedELISA, WB, IHC281.2580 µlQ13323RUO

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