Bcl-2-Like Protein 1 (BCL2L1) Antibody
377€ (100 µg)
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Name
Bcl-2-Like Protein 1 (BCL2L1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx230842
Tested Applications
ELISA, WB, IHC, IF/ICC, IP
Description
BCL2L1 Antibody is a Rabbit Polyclonal against BCL2L1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Bcl-2-Like Protein 1 (BCL2L1) Immunogen: BCL2-like 1 |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/1000 - 1/6000, IHC: 1/50 - 1/500, IF/ICC: 1/50 - 1/500, IP: 1/500 - 1/3000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 30 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q07817 |
| Alias | BCLX,BCL2L,Bcl-X,PPP1R52; BCL-XL/S,Apoptosis regulator Bcl-X |
| Background | Antibody anti-BCL2L1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
BCL2 like 1 (BCL2L1), also known as BCL-XL, is a well-known anti-apoptotic protein that regulates cell survival by preventing mitochondrial apoptosis BCL2L1 is part of the Bcl-2 family of proteins, which includes both pro- and anti-apoptotic members, and it plays a crucial role in inhibiting the release of cytochrome c from mitochondria, thus blocking caspase activation and preventing apoptosis BCL2L1 is highly expressed in various cell types, including immune cells, neurons, and cancer cells, where it supports cell survival and promotes tissue homeostasis Dysregulation of BCL2L1 has been associated with cancer, where its overexpression protects tumor cells from chemotherapy-induced apoptosis and promotes tumor progression In addition to its role in cancer, BCL2L1 is involved in regulating immune responses and neuronal function, particularly in protecting against neurodegenerative diseases like Alzheimer’s and Parkinson’s Recent studies also highlight its importance in cell metabolism, autophagy, and inflammation, further emphasizing its role as a critical regulator of cellular fate and survival
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