BCL2L1 (pS62) Antibody
208€ (20 µl)
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Name
BCL2L1 (pS62) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx000362
Tested Applications
WB, IF/ICC
Description
BCL2L1 (pS62) Antibody is a Rabbit Polyclonal antibody against BCL2L1 (pS62). The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: BCL2L1 (pS62) Immunogen: A phospho specific peptide corresponding to residues surrounding S62 of human Bcl-XL |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 26 kDa Observed MW: 30 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q07817 |
| Gene ID | 598 |
| Alias | BCLX,BCL2L,Bcl-X,PPP1R52; BCL-XL/S,Apoptosis regulator Bcl-X |
| Background | Antibody anti-BCL2L1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
BCL2 like 1 (BCL2L1), also known as BCL-XL, is a well-known anti-apoptotic protein that regulates cell survival by preventing mitochondrial apoptosis BCL2L1 is part of the Bcl-2 family of proteins, which includes both pro- and anti-apoptotic members, and it plays a crucial role in inhibiting the release of cytochrome c from mitochondria, thus blocking caspase activation and preventing apoptosis BCL2L1 is highly expressed in various cell types, including immune cells, neurons, and cancer cells, where it supports cell survival and promotes tissue homeostasis Dysregulation of BCL2L1 has been associated with cancer, where its overexpression protects tumor cells from chemotherapy-induced apoptosis and promotes tumor progression In addition to its role in cancer, BCL2L1 is involved in regulating immune responses and neuronal function, particularly in protecting against neurodegenerative diseases like Alzheimer’s and Parkinson’s Recent studies also highlight its importance in cell metabolism, autophagy, and inflammation, further emphasizing its role as a critical regulator of cellular fate and survival
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