Bcl-2-Like Protein 1 (BCL2L1) Antibody
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935106861
info@markelab.com
Precio
281.25€ (50 µg)
Antibody anti-BCL2L1
proveedor
Abbexareference
abx210144Tested Applications
ELISA, WB, IHCreactivity
Humanstatus
RUOclonality
MonoclonalDescripción
Bcl-2-like protein 1 Antibody is a Mouse Monoclonal against Bcl-2-like protein 1.
Background
BCL2 like 1 (BCL2L1), also known as BCL-XL, is a well-known anti-apoptotic protein that regulates cell survival by preventing mitochondrial apoptosis BCL2L1 is part of the Bcl-2 family of proteins, which includes both pro- and anti-apoptotic members, and it plays a crucial role in inhibiting the release of cytochrome c from mitochondria, thus blocking caspase activation and preventing apoptosis BCL2L1 is highly expressed in various cell types, including immune cells, neurons, and cancer cells, where it supports cell survival and promotes tissue homeostasis Dysregulation of BCL2L1 has been associated with cancer, where its overexpression protects tumor cells from chemotherapy-induced apoptosis and promotes tumor progression In addition to its role in cancer, BCL2L1 is involved in regulating immune responses and neuronal function, particularly in protecting against neurodegenerative diseases like Alzheimer’s and Parkinson’s Recent studies also highlight its importance in cell metabolism, autophagy, and inflammation, further emphasizing its role as a critical regulator of cellular fate and survival
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human
immunogen target
Bcl-2-Like Protein 1 (BCL2L1)
host
Mouse
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purity
> 95%
purification
Purified by Protein G.
buffer
0.01 M PBS, pH 7.4, 0.03% Proclin 300 and 50% glycerol.
size 1
50 µg
size 2
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
BCL2L1
dry ice
No
availability
Shipped within 5-10 working days.
alias
BCLX,BCL2L,Bcl-X,PPP1R52; BCL-XL/S,Apoptosis regulator Bcl-X
uniprot id
NCBI accession
NP_001182.1, NM_001191.3, NP_001304848.1, NM_001317919.1
note
This product is for research use only.
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