The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells.
B-cell activating factor (BAFF), also called tumor necrosis factor ligand superfamily member 13B (TNFSF13B) and CD257, is a protein encoded by the TNFSF13B gene in humans. BAFF is also known by other names, including B Lymphocyte Stimulator (BLyS),CD257, TNF- and APOL-related leukocyte expressed ligand (TALL-1). The human BAFF protein consists of two glycosylated domains and one transmembrane domain (amino acids 48-68), and it can undergo cleavage into both membrane-bound and soluble peptide fragments. BAFF is primarily expressed in cells within the B cell lineage and serves as a potent activator of B cells. It plays a crucial role in promoting the proliferation and differentiation of B cells, making it a pivotal cytokine in the immune system's function.
El factor activador de células B (BAFF), también llamado miembro 13B de la superfamilia del ligando del factor de necrosis tumoral (TNFSF13B) y CD257, es una proteína codificada por el gen TNFSF13B en humanos. BAFF también se conoce con otros nombres, incluido estimulador de linfocitos B (BLyS), CD257, y TALL-1 (APOL-related leukocyte expressed ligand). La proteína BAFF humana consta de dos dominios glicosilados y un dominio transmembrana (aminoácidos 48-68) y puede sufrir escisión en fragmentos peptídicos solubles y unidos a la membrana. BAFF se expresa principalmente en células del linaje de células B y sirve como un potente activador de las células B. Desempeña un papel crucial en la promoción de la proliferación y diferenciación de las células B, lo que la convierte en una citoquina fundamental en la función del sistema inmunológico.
Primary Antibodies
Polyclonal
Human
Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B)
Rabbit
Unconjugated
Liquid
ELISA, WB, IHC
Purified through a protein A column, followed by peptide affinity purification.
PBS containing 0.09% sodium azide.
80 µl
400 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
TNFSF13B
No
Shipped within 5-10 working days.
B lymphocyte stimulator,BLyS,BAFF,B-cell-activating factor
This product is for research use only.
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