TNFSF13B Antibody is a Rabbit Polyclonal antibody against TNFSF13B. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
B-cell activating factor (BAFF), also called tumor necrosis factor ligand superfamily member 13B (TNFSF13B) and CD257, is a protein encoded by the TNFSF13B gene in humans. BAFF is also known by other names, including B Lymphocyte Stimulator (BLyS),CD257, TNF- and APOL-related leukocyte expressed ligand (TALL-1). The human BAFF protein consists of two glycosylated domains and one transmembrane domain (amino acids 48-68), and it can undergo cleavage into both membrane-bound and soluble peptide fragments. BAFF is primarily expressed in cells within the B cell lineage and serves as a potent activator of B cells. It plays a crucial role in promoting the proliferation and differentiation of B cells, making it a pivotal cytokine in the immune system's function.
El factor activador de células B (BAFF), también llamado miembro 13B de la superfamilia del ligando del factor de necrosis tumoral (TNFSF13B) y CD257, es una proteína codificada por el gen TNFSF13B en humanos. BAFF también se conoce con otros nombres, incluido estimulador de linfocitos B (BLyS), CD257, y TALL-1 (APOL-related leukocyte expressed ligand). La proteína BAFF humana consta de dos dominios glicosilados y un dominio transmembrana (aminoácidos 48-68) y puede sufrir escisión en fragmentos peptídicos solubles y unidos a la membrana. BAFF se expresa principalmente en células del linaje de células B y sirve como un potente activador de las células B. Desempeña un papel crucial en la promoción de la proliferación y diferenciación de las células B, lo que la convierte en una citoquina fundamental en la función del sistema inmunológico.
Primary Antibodies
Polyclonal
Human, Mouse, Rat
Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B)
Rabbit
Unconjugated
Liquid
WB, IHC, IF/ICC
Purified by affinity chromatography.
PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
20 µl
50 µl
100 µl
200 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
No
Shipped within 5-10 working days.
B lymphocyte stimulator,BLyS,BAFF,B-cell-activating factor
NP_006564.1
This product is for research use only.
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