Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) Antibody (FITC)

494€ (100 tests)
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935106861
info@markelab.com
name
Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx270490
tested applications
FCM
Description
Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) Antibody (FITC) is a Rabbit Polyclonal Antibody conjugated to FITC against Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) for use in flow cytometry.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) |
Host | Rabbit |
Reactivity | Mouse |
Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | FITC |
Isotype | IgG |
Purification | Purified by antigen-specific affinity chromatography. |
Size 1 | 100 tests |
Size 2 | 200 tests |
Size 3 | 500 tests |
Form | Liquid |
Tested Applications | FCM |
Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
Availability | Please enquire. |
Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q9WU72 |
Gene ID | 24099 |
OMIM | 603969 |
Alias | Tumor necrosis factor ligand superfamily member 13B,DTL,BAFF,BLYS,CD257,TALL1,THANK,ZTNF4,TALL-1,TNLG7A,TNFSF20,B lymphocyte stimulator,BLyS,Dendritic cell-derived TNF-like molecule,TNF- and APOL-related leukocyte expressed ligand 1 |
Background | Antibody anti-TNFSF13B |
Status | RUO |
Descripción
TNFSF13B, commonly known as BAFF (B-cell activating factor), is a cytokine that belongs to the tumor necrosis factor (TNF) superfamily and is critical for B cell survival, maturation, and immune function. This ligand is primarily produced by myeloid cells, such as monocytes, macrophages, and dendritic cells, but can also be secreted by activated T cells. BAFF plays a pivotal role in maintaining peripheral B cell populations, supporting antibody production, and promoting immune tolerance. It interacts with specific receptors on B cells and related immune cells, including BAFF-R, TACI (Transmembrane Activator and Calcium-Modulating Cyclophilin Ligand Interactor), and BCMA (B Cell Maturation Antigen), to initiate intracellular signaling pathways crucial for B cell homeostasis and function. Dysregulation of BAFF expression or receptor binding is associated with autoimmune diseases, such as systemic lupus erythematosus (SLE), multiple sclerosis, and rheumatoid arthritis.
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