Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) Antibody (PE)

Product specifications

Primary Antibodies

Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B)

Rabbit

Mouse

FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

PE

IgG

Purified by antigen-specific affinity chromatography.

100 tests

200 tests

500 tests

Liquid

FCM

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.

Please enquire.

Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light.

No

Q9WU72

24099

603969

Tumor necrosis factor ligand superfamily member 13B,DTL,BAFF,BLYS,CD257,TALL1,THANK,ZTNF4,TALL-1,TNLG7A,TNFSF20,B lymphocyte stimulator,BLyS,Dendritic cell-derived TNF-like molecule,TNF- and APOL-related leukocyte expressed ligand 1

Antibody anti-TNFSF13B

RUO

Descripción

TNFSF13B, commonly known as BAFF (B-cell activating factor), is a cytokine that belongs to the tumor necrosis factor (TNF) superfamily and is critical for B cell survival, maturation, and immune function. This ligand is primarily produced by myeloid cells, such as monocytes, macrophages, and dendritic cells, but can also be secreted by activated T cells. BAFF plays a pivotal role in maintaining peripheral B cell populations, supporting antibody production, and promoting immune tolerance. It interacts with specific receptors on B cells and related immune cells, including BAFF-R, TACI (Transmembrane Activator and Calcium-Modulating Cyclophilin Ligand Interactor), and BCMA (B Cell Maturation Antigen), to initiate intracellular signaling pathways crucial for B cell homeostasis and function. Dysregulation of BAFF expression or receptor binding is associated with autoimmune diseases, such as systemic lupus erythematosus (SLE), multiple sclerosis, and rheumatoid arthritis.

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