Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands-2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor(BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
B-cell activating factor (BAFF), also called tumor necrosis factor ligand superfamily member 13B (TNFSF13B) and CD257, is a protein encoded by the TNFSF13B gene in humans. BAFF is also known by other names, including B Lymphocyte Stimulator (BLyS),CD257, TNF- and APOL-related leukocyte expressed ligand (TALL-1). The human BAFF protein consists of two glycosylated domains and one transmembrane domain (amino acids 48-68), and it can undergo cleavage into both membrane-bound and soluble peptide fragments. BAFF is primarily expressed in cells within the B cell lineage and serves as a potent activator of B cells. It plays a crucial role in promoting the proliferation and differentiation of B cells, making it a pivotal cytokine in the immune system's function.
El factor activador de células B (BAFF), también llamado miembro 13B de la superfamilia del ligando del factor de necrosis tumoral (TNFSF13B) y CD257, es una proteína codificada por el gen TNFSF13B en humanos. BAFF también se conoce con otros nombres, incluido estimulador de linfocitos B (BLyS), CD257, y TALL-1 (APOL-related leukocyte expressed ligand). La proteína BAFF humana consta de dos dominios glicosilados y un dominio transmembrana (aminoácidos 48-68) y puede sufrir escisión en fragmentos peptídicos solubles y unidos a la membrana. BAFF se expresa principalmente en células del linaje de células B y sirve como un potente activador de las células B. Desempeña un papel crucial en la promoción de la proliferación y diferenciación de las células B, lo que la convierte en una citoquina fundamental en la función del sistema inmunológico.
Primary Antibodies
polyclonal
human,mouse
tumor necrosis factor(ligand) superfamily, member 13b
Rabbit
IgG
Unconjugated
liquid
ELISA, WB
32 kDa,45-52 kDa
≥95% as determined by SDS-PAGE
Immunogen affinity purified
WB: 1:500-1:2000
100µg
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
TNFSF13B
BAFF, BLYS, TALL1, TNFSF20, ZTNF4
This product is for research use only.
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Ver másHuman Tumor Necrosis Factor Ligand Superfamily Member 13B (BAFF/CD257) Chemiluminescent Immunoassay (CLIA) Kit is a Chem...
618.75€ (96 tests)
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