Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) Antibody
357.5€ (100 µg)
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935106861
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name
Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx145020
tested applications
ELISA, WB
Description
TNFSF13B Antibody is a Rabbit Polyclonal against TNFSF13B.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y275 |
| Gene ID | 10673 |
| NCBI Accession | BC020674 |
| OMIM | 603969 |
| Alias | Tumor necrosis factor ligand superfamily member 13B,DTL,BAFF,BLYS,CD257,TALL1,THANK,ZTNF4,TALL-1,TNLG7A,TNFSF20,B lymphocyte stimulator,BLyS,Dendritic cell-derived TNF-like molecule,TNF- and APOL-related leukocyte expressed ligand 1 |
| Background | Antibody anti-TNFSF13B |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
TNFSF13B, commonly known as BAFF (B-cell activating factor), is a cytokine that belongs to the tumor necrosis factor (TNF) superfamily and is critical for B cell survival, maturation, and immune function. This ligand is primarily produced by myeloid cells, such as monocytes, macrophages, and dendritic cells, but can also be secreted by activated T cells. BAFF plays a pivotal role in maintaining peripheral B cell populations, supporting antibody production, and promoting immune tolerance. It interacts with specific receptors on B cells and related immune cells, including BAFF-R, TACI (Transmembrane Activator and Calcium-Modulating Cyclophilin Ligand Interactor), and BCMA (B Cell Maturation Antigen), to initiate intracellular signaling pathways crucial for B cell homeostasis and function. Dysregulation of BAFF expression or receptor binding is associated with autoimmune diseases, such as systemic lupus erythematosus (SLE), multiple sclerosis, and rheumatoid arthritis.
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