Atypical Chemokine Receptor 3 (ACKR3) Antibody (PE)
429€ (100 tests)
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935106861
info@markelab.com
name
Atypical Chemokine Receptor 3 (ACKR3) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx347180
tested applications
FCM
Description
Atypical Chemokine Receptor 3 (ACKR3) Antibody (PE) is a mouse monoclonal antibody against Atypical Chemokine Receptor 3 (ACKR3).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Atypical Chemokine Receptor 3 (ACKR3) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | FCM: 10 μl/100 μl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG2a Kappa |
| Clone ID | M647 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P25106 |
| Gene ID | 57007 |
| OMIM | 610376 |
| Alias | chemokine (C-X-C motif) receptor 7,chemokine orphan receptor 1,CXCR7,Cxcr7,GPR159 ,G-protein coupled receptor 159,RDC-1,RDC1,CMKOR11 |
| Background | Antibody anti-ACKR3 |
| Status | RUO |
Descripción
ACKR3, also known as CXCR7, is an atypical chemokine receptor that binds CXCL12 and CXCL11 but does not trigger classical G protein signaling. Instead, it functions as a "scavenger receptor," internalizing and degrading chemokines to regulate their extracellular levels. ACKR3 is expressed on endothelial cells, smooth muscle cells, and cancer cells and plays a critical role in modulating chemokine gradients, which control immune cell migration. In cancer, ACKR3 is frequently overexpressed and promotes tumor growth, survival, and metastasis by scavenging CXCL12, enhancing CXCR4-mediated signaling. It is involved in glioblastoma, breast, and prostate cancers, where its expression correlates with poor prognosis and therapy resistance. ACKR3 also contributes to angiogenesis by promoting endothelial cell migration and tube formation. In the central nervous system, it regulates CXCL12 availability, impacting neurogenesis and neuronal repair. While it does not induce typical signaling, ACKR3 activates β-arrestin-dependent pathways that influence cellular adhesion, survival, and proliferation. Its atypical signaling and scavenging activity make ACKR3 an attractive target for cancer therapy and inflammatory disease treatment.
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