ATP/GTP Binding Protein Like 4 (AGBL4) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
ATP/GTP Binding Protein Like 4 (AGBL4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx323530
tested applications
ELISA, WB
Description
AGBL4 Antibody is a Rabbit Polyclonal against AGBL4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP/GTP Binding Protein Like 4 (AGBL4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5VU57 |
| Gene ID | 84871 |
| Alias | CCP6 |
| Background | Antibody anti-AGBL4 |
| Status | RUO |
Descripción
AGBL4 is an enzyme involved in the deglutamylation of tubulin, a critical process for regulating microtubule dynamics and stability. It removes polyglutamate side chains from the C-terminal tails of tubulin, thereby influencing microtubule-based transport, axon guidance, and neuronal plasticity. AGBL4 is expressed in various tissues, including the brain, heart, and skeletal muscle, suggesting a role in both neuronal and muscular function. Dysregulation of AGBL4 has been associated with neurological disorders, where defective tubulin modifications impair intracellular transport, leading to synaptic dysfunction and neurodegeneration. Emerging research also implicates AGBL4 in certain cancers, where altered microtubule stability can drive aberrant cell division and migration. The enzyme’s activity is crucial for maintaining the delicate balance of tubulin modifications required for normal cellular and tissue homeostasis.
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