ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody
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Description
Rabbit Polyclonal against the ATP1B3 protein.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Sodium/potassium-transporting ATPase subunit beta-3,CD298,ATPB-3, |
| Background | Antibody anti-ATP1B3 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
The ATPase Na+/K+ transporting subunit beta 3 (ATP1B3) is a critical protein involved in maintaining cellular ionic balance through the sodium-potassium (Na+/K+) pump, an essential enzyme for cellular homeostasis. ATP1B3 is one of the beta subunits of this Na+/K+-ATPase complex, which actively transports sodium (Na+) out of cells and potassium (K+) into cells against their concentration gradients using energy from ATP hydrolysis. The proper functioning of this pump is vital for generating the membrane potential, controlling cell volume, and enabling various cellular processes such as nerve impulse transmission, muscle contraction, and maintaining cell polarity. ATP1B3 is expressed in many tissues, particularly in those involved in high rates of ion transport, such as neural, cardiac, and renal tissues.
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The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ ATPases. Na+/K+ ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq].
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