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The ATPase Na+/K+ transporting subunit beta 3 (ATP1B3) is a critical protein involved in maintaining cellular ionic balance through the sodium-potassium (Na+/K+) pump, an essential enzyme for cellular homeostasis. ATP1B3 is one of the beta subunits of this Na+/K+-ATPase complex, which actively transports sodium (Na+) out of cells and potassium (K+) into cells against their concentration gradients using energy from ATP hydrolysis. The proper functioning of this pump is vital for generating the membrane potential, controlling cell volume, and enabling various cellular processes such as nerve impulse transmission, muscle contraction, and maintaining cell polarity. ATP1B3 is expressed in many tissues, particularly in those involved in high rates of ion transport, such as neural, cardiac, and renal tissues.
The ATP1B3 protein structure is crucial to its function within the Na+/K+-ATPase complex. ATP1B3, as a beta subunit, primarily has a supportive role in the structural integrity, stability, and regulation of the enzyme. Here’s a closer look at the structural components:
Transmembrane Domain:
Extracellular Domain:
Cytoplasmic Tail:
Alpha-Beta Interaction:
The Na+/K+-ATPase is a heterodimeric enzyme complex composed of alpha, beta, and gamma subunits. The beta subunits (including ATP1B3) are classified based on their genetic and structural characteristics and tissue distribution. In the Na+/K+-ATPase complex:
The biological significance of ATP1B3 lies in its role as part of the Na+/K+-ATPase complex. ATP1B3 contributes to multiple essential functions:
Ion Homeostasis:
Membrane Potential and Excitability:
Cell Adhesion and Signaling:
Protein Stabilization and Folding:
Apoptotic Regulation:
Cardiac Disorders:
Neurological Conditions:
Hypertension:
Autoimmune Disorders:
Cancer:
ATP1B3, the beta 3 subunit of the Na+/K+-ATPase complex, plays a fundamental role in maintaining ion homeostasis and supporting cellular functions related to membrane potential and cell adhesion. Its structure, comprising a transmembrane domain, extracellular glycosylated domain, and cytoplasmic tail, is essential for its function within the Na+/K+ pump and its interactions with other cellular components. ATP1B3’s presence in diverse tissues, including neural and cardiac tissues, underscores its broad physiological significance, particularly in excitable cells.
Clinically, ATP1B3 is implicated in various health conditions, including cardiac arrhythmias, neurological disorders, hypertension, and autoimmune diseases, with potential roles in cancer. Its role in maintaining cellular ion gradients makes it a vital component in excitable tissues, and disruptions in its function can have significant pathological consequences. The study of ATP1B3 continues to provide insights into the complex regulatory networks underlying ion transport, cellular excitability, and intercellular communication, emphasizing its potential as a therapeutic target for conditions involving ion imbalance and cellular signaling.
ATPase Na+/K+ transporting subunit beta 3 (ATP1B3)
Sodium/potassium-transporting ATPase subunit beta-3,CD298,ATPB-3,
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con ATP1B3 - ATPase Na+/K+ transporting subunit beta 3
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | ATP1B3 | abx385934 | Human ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.19 ng/ml | 618.75 | 96 tests | P54709 | RUO |
Abbexa | ATP1B3 | abx491929 | Mouse ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) CLIA Kit | Mouse | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.066 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | ATP1B3 | abx153688 | Mouse ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | ATP1B3 | abx155239 | Rat ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) ELISA Kit | Rat | Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.08 ng/ml | 675 | 96 tests | RUO | |
Abbexa | ATP1B3 | abx491930 | Rat ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) CLIA Kit | Rat | Tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.071 ng/ml | 812.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ATP1B3 | abx026991 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody | Human | Polyclonal | Rabbit | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | P54709 | RUO | |
Abbexa | ATP1B3 | abx274482 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody (FITC) | Human | Polyclonal | Rabbit | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | FITC | WB, IHC, IF/ICC | 400 | 200 µl | RUO | ||
Abbexa | ATP1B3 | abx303159 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody (HRP) | Human | Polyclonal | Rabbit | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | HRP | ELISA | 162.5 | 20 µg | P54709 | RUO | |
Abbexa | ATP1B3 | abx303161 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody (Biotin) | Human | Polyclonal | Rabbit | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | Biotin | ELISA | 162.5 | 20 µg | P54709 | RUO | |
Abbexa | ATP1B3 | abx036376 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody | Human | Polyclonal | Rabbit | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | Unconjugated | ELISA, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | ATP1B3 | abx104466 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody | Human | Polyclonal | Rabbit | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | RUO | ||
Abbexa | ATP1B3 | abx323351 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody | Human | Polyclonal | Rabbit | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P54709 | RUO | |
Abbexa | ATP1B3 | abx014907 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody | Human | Polyclonal | Rabbit | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | Unconjugated | ELISA, WB | 43.75 | 10 µg | P54709 | RUO | |
Abbexa | ATP1B3 | abx303158 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody | Human | Polyclonal | Rabbit | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | P54709 | RUO | |
Abbexa | ATP1B3 | abx323287 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody | Human | Polyclonal | Rabbit | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P54709 | RUO | |
Abbexa | ATP1B3 | abx303160 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody (FITC) | Human | Polyclonal | Rabbit | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | FITC | 162.5 | 20 µg | P54709 | RUO | ||
Abbexa | ATP1B3 | abx111158 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody | Human | Polyclonal | Rabbit | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | P54709 | RUO | |
Abbexa | ATP1B3 | abx129651 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody | Mouse | Polyclonal | Rabbit | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P97370 | RUO | |
Abbexa | ATP1B3 | abx171366 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody | Rat | Monoclonal | Mouse | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | Unconjugated | WB, IHC, IF/ICC | 775 | 1 ml | RUO | ||
Abbexa | ATP1B3 | abx130256 | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Antibody | Rat | Polyclonal | Rabbit | ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q63377 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ATP1B3 | abx167774 | Rat ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | Q63377 | RUO |
Abbexa | ATP1B3 | abx262767 | ATPase Transporting beta 3 Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | P54709 | RUO | ||
Abbexa | ATP1B3 | abx167447 | Mouse ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P97370 | RUO |
Abbexa | ATP1B3 | abx065480 | Human ATPase, Na+/K+ Transporting Beta 3 Polypeptide (ATP1B3) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P54709 | RUO |
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