ATP-Dependent Translocase ABCB1 (ABCB1) Antibody (Biotin)

Este producto es parte de ABCB - ATP binding cassette subfamily B member
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377€ (200 µl)

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935106861
info@markelab.com
name
ATP-Dependent Translocase ABCB1 (ABCB1) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx271437
tested applications
WB, IHC, IF/ICC

Description

ATP-Dependent Translocase ABCB1 (ABCB1) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against ATP-Dependent Translocase ABCB1 (ABCB1) / Permeability Glycoprotein (Pgp).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
ATP-Dependent Translocase ABCB1 (ABCB1)
Host
Rabbit
Reactivity
Mouse
Recommended Dilution
WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Biotin
Isotype
IgG
Purification
Purified by antigen-specific affinity chromatography.
Size 1
200 µl
Size 2
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P06795
Gene ID
18669
Alias
ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,p-170
Background
Antibody anti-ABCB1
Status
RUO

Descripción

ABCB1, also known as P-glycoprotein, is a well-studied ATP-dependent efflux transporter involved in the transport of a wide range of substrates, including drugs, lipids, and xenobiotics. It is highly expressed in barrier tissues, such as the blood-brain barrier, intestines, liver, and kidneys, where it functions to protect tissues by actively exporting toxic compounds and drugs. ABCB1 plays a crucial role in pharmacokinetics, influencing drug absorption, distribution, and elimination. Overexpression of ABCB1 in cancer cells is a major contributor to multidrug resistance, as it pumps chemotherapeutic agents out of cells, reducing their efficacy. Structurally, ABCB1 contains two transmembrane domains and two ATP-binding domains, which utilize ATP hydrolysis to drive substrate transport. Its pivotal role in drug resistance and detoxification makes it a significant target in cancer therapy and pharmacological research.

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